probiotics lactobacillus plantarum and bifidobacterium b94: cognitive function in demyelinated model

نویسندگان

mahdi goudarzvand department of pharmacology-physiology, school of medicine, alborz university of medical sciences, karaj, iran.

samira rasouli koohi antimicrobial resistance research centre, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran.

zohreh khodaii dietary supplements and probiotic research center, alborz university of medical sciences, karaj, iran.

somayeh soleymanzadeh moghadam antimicrobial resistance research centre, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran.

چکیده

background: multiple sclerosis (ms) is a disease of the immune system that creates damage of learning and memory in that. using probiotic supplements is recommended for preventing ms disease and improving memory. this study aimed to investigate the effect of lactobacillus plantarum (lp) and bifidobacterium b94 (bb94), on acquisition phase of spatial memory in the local demyelination of rats` hippocampus.   methods: in this study, 32 male wistar rats were divided into control, damage group and treatment groups. treatment groups were including (lp) and (bb94). after the induction of demyelination by 3 μl of eb into the right dentate gyrus of the hippocampus in treatment groups, 1.5×108 probiotic bacteria were administered by gavage for 28 days. data was analyzed using one-way anova and tukey post-hoc tests (p≤0.05).   results: findings demonstrated that injection of eb caused a significant increase in traveled distance (p<0.01) and also escape latency (p<0.05) compared with control group. also, effect administrations of (lp) and (bb94) on traveled distance and escape latency were reviewed, and it was determined that administration of them do not cause significant reduction in the traveled distance compared with the lesion group. also mentioned probiotics has no significant effect on swimming speed compared with lesion and saline groups.    conclusion: according to some studies, probiotics have a positive impact on improving the performance of spatial memory and learning, although the results of the current study could not indicate finality of this assumption.  it seems that more researches is needed on this subject.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Probiotics Lactobacillus plantarum and Bifidobacterium B94: cognitive function in demyelinated model

&nbsp;&nbsp;Background: Multiple Sclerosis (MS) is a disease of the immune system that creates damage of Learning and memory in that. Using probiotic supplements is recommended for preventing MS disease and improving memory. This study aimed to investigate the effect of Lactobacillus Plantarum (LP) and bifidobacterium B94 (BB94), on acquisition phase of spatial memory in the local demyelination...

متن کامل

Probiotics Lactobacillus plantarum and bifidobacterium B94: cognitive function in demyelinated model

BACKGROUND Multiple Sclerosis (MS) is a disease of the immune system that creates damage of Learning and memory in that. Using probiotic supplements is recommended for preventing MS disease and improving memory. This study aimed to investigate the effect of Lactobacillus plantarum (LP) and bifidobacterium B94 (BB94), on acquisition phase of spatial memory in the local demyelination of rats` hip...

متن کامل

بررسی تغییرات سطح سرمی Fe+2 و ویتامین D3 به دنبال مصرف پروبیوتیک‌ها در دمیلیناسیون ناشی از اتیدیوم بروماید هیپوکمپ موش صحرایی

 Background: Recently, using probiotics for preventing and treating the immune system diseases via increasing the absorption of protective factors has attracted the attention of researchers. The aim of the present study was to evaluate the effect of probiotic bacteria, Lactobacillus plantarum 299v and Bifidobacteria B94, on serum Fe +2 and vitamin D3 levels following ethidium bromide - ...

متن کامل

Effects of Two Probiotics, Lactobacillus Plantarum and Lactobacillus Bulgaricus on Growth Performance and Intestinal Lactic Acid Bacteria of Cyprinus Carpio

Background: The application of probiotics to aquaculture is rather new. Probiotics affect the intestinal microbial flora of fish and subsequently modulate its immune response and growth performance. OBJECTIVES: This study was conducted to evaluate the effect of food supplementation with L.plantarum and L.bulgaricus on growth performance and gut microbiota of Cyprinus carpio. METHODS: For this p...

متن کامل

Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses.

OBJECTIVE To assess impact of probiotics and breastfeeding on gut microecology. STUDY DESIGN Mothers were randomized to receive placebo or Lactobacillus rhamnosus GG before delivery, with treatment of the infants after delivery. We assessed gut microbiota, humoral immune responses, and measured soluble cluster of differentiation 14 (sCD14) in colostrum in 96 infants. RESULTS Fecal Bifidobac...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۳۰، شماره ۱، صفحات ۶۴۷-۶۵۳

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023